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pentobarbital will lessen the level or effect of darunavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.Contraindicated (1)pentobarbital will decrease the level or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is to blame for the formation and elimination o